Pain pathway includes transduction at the peripheral receptor-conduction through pain neurons-spinal cord transmission to thalamus which is a major pain center-perception at sensory level. Neuropathic pain is caused by damage to the pathway to the thalamus.
Neuropathic pain can be peripheral or central to thalamus.
Example of neuropathic pains are:
- Diabetic neuropathy
- Peripheral Neuropathy
- Post Herpetic neuralgia
- Phantom Limb Pain
- Failed Back syndrome after spinal surgery
- Nerve compression
- Lyme disease
Patients often experience shooting and burning pain with tingling and numb sensation.
Patients who are refractory to conventional antidepressant and anticonvulsant treatment may experience immediate relief of pain.